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KMID : 0860920100120020145
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Journal of the Korean Association EMG-Electrodiagnostic Medicine
2010 Volume.12 No. 2 p.145 ~ p.146
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Pemphigus Vulgaris Simultaneously Developed with Myasthenia Gravis in Thymoma
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Minn Yang-Ki
Cho Soo-Jin
Shin Ho-Seung
Ku Kyung-Mo
Kim Yu-Kyung
Park Won-Hwa
Kwon Ki-Han
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Abstract
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Paraneoplatic pemphigus vularis associated with thymoma is an autoimmune disease to epithelial cell in Hassall’s corpuscle, thymus medulla and myasthenia gravis is to myoid cell in thymus cortex. Because most thymic tumor is cortex tumor, myoid cell may exposed to immune system earlier than epithelial cell and myasthenia gravis may be proceeding to pemphigus. Forty-four year old woman developed pemphigus vulgaris and myasthenia gravis simultaneously. After herbal medication, myasthenia gravis and pemphigus were worsened together. Thymoma was discovered and its WHO grade was B2. We hypothesize that in high grade thymoma, two type of different antigen could present to autoimmune mechanism simultaneously. And they could be processed together.
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KEYWORD
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Pemphigus vulgaris, Myasthenia gravis, Thymoma, Autoimmune disease
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